Elix is a supporting antagonist in Invincible, debuting in Season 4 and onwards.

She is a ruthless Viltrumite warrior of the Viltrum Empire, committed to its mission of universal domination. Following Viltrum's destruction, Elix resettled into Earth's human society to find suitable mates to interbreed with and repopulate the Empire.

Supporting character from invincible

Amber Bennett was a previous friend and romantic partner to Mark Grayson, but the two have since broken up. She serves as a supporting character for the first dozen issues of Invincible

From the Invincible Comic Series

Leslie Willis, also known as Livewire, is a major antagonist in Superman: The Animated Series and a minor antagonist in The New Batman Adventures, Justice League, and Justice League: Unlimited. She is an electrokinetic supervillain and an enemy of Superman. She was voiced by Lori Petty in Superman: The Animated Series and by Maria Canals-Barrera in Justice League Unlimited.

From the DCAU

Maria Robotnik[4] (マリア・ロボトニック[8], Maria Robotonikku?) is a character that appears in the Sonic the Hedgehog series. She was a young human, the granddaughter of Gerald Robotnik and the cousin of Dr. Eggman. Born on Earth, Maria suffered from a terminal illness with no known cure. To save Maria, Gerald brought her aboard the Space Colony ARK to keep her condition in remission, while he worked on Project Shadow in hopes of developing a cure. Gerald's research produced Shadow the Hedgehog.

granddaughter of Gerald Robotnik

Samantha Eve Wilkins, later known as Atom Shiva is an alternate universe counterpart of Atom Eve and a major antagonist in Brit: Fubhar. Unlike the main counterpart, Atom Shiva was powerful tyrant, and continued her relationship with Rex Sloan who in this universe is Hex Splode.

Atom eves evil counterpart

May Parker (née Reilly) was the wife of Ben Parker and lived in Forest Hills, New York City. She raised her orphan nephew, Peter Parker. May Parker is Peter Parker's aunt and widow of Ben Parker.

From the XD Ultimate Series

Felicia Hardy is the daughter of a business woman and a world renowned thief. After Felicia was given the Super Soldier Serum, she was transformed into a super soldier. Felicia then took the name Black Cat and became a criminal. However, Black Cat later changed her ways and became an ally to Spider-Man.

From the 90’s animated series

Gwen Stacy (Clone) (of Earth-1610), also known as Carnage and the "Stacy Experiment", is a clone of the original Gwen Stacy created by Otto Octavius and Ben Reilly using a combination of the original's and Carnage's DNA.

From the 1610 comics

Mary Jane "MJ" Watson is the deuteragonist of Insomniac's Spider-Man video game series.
A Daily Bugle reporter, she is a friend and love interest of Peter Parker, and is aware of his secret identity as Spider-Man. Part of her story involves an investigation into who is behind the events happening in New York City, which culminates in her breaking into Norman Osborn's penthouse. After the Devil's Breath incident, MJ assists Peter and his protégé and the new Spider-Man, Miles Morales, in battling

From the insomniac games

Dr. Harleen Quinzel, known more commonly as Harley Quinn, is a major antagonist in the DC Animated Universe. She was originally the Joker's psychiatrist before becoming his accomplice and on-and-off girlfriend after madly falling in love with him, but eventually struck out on her own. She is often aided in her crimes by her best friend and fellow Arkham Asylum inmate, Poison Ivy. She is also the archenemy of Batgirl, and eventually joined Suicide Squad during Batman: The Adventures Continue Sea

From BTAS

Ace of Clubs, better known as just Ace, is a minor antagonist in the DC Animated Universe. She's a powerful metahuman who was a member of Joker's Royal Flush Gang. Ace possessed the ability to cause sensory hallucinations that can cause insanity on anyone who stares her in the eye, which eventually evolved into the power to manipulate reality itself. Following the defeat of the original Royal Flush Gang, Ace would form a second team consisting of brainwashed civilians.

Harry Osborn was a friend of Peter Parker and the son of Norman Osborn. Harry later became Peter's enemy as the second Green Goblin.

From the animated series 

Kaze and Sapphire are major original characters in Tales of Origin, a Sonic the Hedgehog fan comic series created by LiyuConberma. Set in an alternate universe filled with magic, war, and romance, Kaze and Sapphire play pivotal roles as star-crossed lovers and the biological parents of Sonic, Shadow, and Silver.

From teens play and children’s play

The “Silver Eyes Gang” refers to the core group of main characters in the Five Nights at Freddy’s: The Silver Eyes graphic novel and its sequels (The Twisted Ones and The Fourth Closet). These characters are childhood friends who reunite in their hometown of Hurricane, Utah to investigate the dark history of Freddy Fazbear’s Pizza, where multiple children — including some of their own friends — vanished years ago.

From the FNAF Graphic novels

Princess Koriand'r, translated in Earth English as Starfire, is a member of the Teen Titans and one of the five main protagonists of Teen Titans Go!. Although this intergalactic princess has trouble adapting to Earth life, she makes up for it with her cute looks, good-natured demeanor, and devastating superpowers courtesy of her kind and experiments by the Psion scientists.

From Teen Titans Go!

Launch (ランチ, Ranchi, lit. "Lunch") is a woman with a strange disorder which causes her to switch between two different personalities each time she sneezes. Her first personality is a blue-haired woman, who is sweet, pure-hearted and cheerful and always ready to help. Her other personality is a blonde-haired woman, who is angry and trigger-happy and commits crimes for money and is quick to respond with gunfire when angered. Neither of Launch's personalities remembers the other's actions.

Launch’s splited personalities 

Dagger (Tandy Bowen) is a major character in the 2024 hero shooter game Marvel Rivals. Dr. Susan Storm-Richards, also known as the Invisible Woman, is a major character in the 2024 superhero shooter game Marvel Rivals.

From Rivals

Throwbolt is a female superhero that was present at the preselection for the new Guardians of the Globe.

For the first 24 issues of the series, the character possessed superhuman strength and invulnerability, and went by the codename Scrap. In issue #25 of the series (October 2009), the character, whose powers had been erased in the previous issue, obtained different powers. Now possessing laser, telescopic and x-ray vision, she goes by the codename Supervision.

From the Dynamo 5

Kneesocks Daemon (ニーソックス・デイモン, Nīsokkusu Deimon) is a major antagonist in Panty & Stocking with Garterbelt, and a protagonist in New PANTY & STOCKING with GARTERBELT. She is the younger of the Daemon sisters. Scanty Daemon (スキャンティ・デイモン, Sukyanti Deimon) is a major antagonist in Panty & Stocking with Garterbelt, and a protagonist in New PANTY & STOCKING with GARTERBELT. She is the older siblings of the Daemon sisters.

high-class demonic commanders

Stockiel "Stocking" Anarchy[2] (アナーキー・ストッキング Anākī Sutokkingu) is the titular co-protagonist of Panty & Stocking with Garterbelt. She is the younger sibling of the Anarchy sisters Pantiel "Panty" Anarchy[2] (アナーキー・パンティ Anākī Pantii, transliterated as "Anarchy Panty") is the titular main protagonist of Panty & Stocking with Garterbelt. She is the older sibling of the Anarchy sisters.[3]

From The Show Panty and Stocking

Mob Bitch NPC is a character in New PANTY & STOCKING with GARTERBELT. She was an actress known for her roles in B-grade horror movies, always portraying the role of the blonde promiscuous girl who always die first. She serves as the main antagonist in Bitch Serial Killer!.

Blonde Serial Killer

Dinah Laurel Lance, also known as Black Canary, is a recurring character in the animated series Justice League Unlimited.
She is voiced by Morena Baccarin.

Omnivincible is a supporting antagonist in the third season of the series. He is an evil variant of main Invincible from another universe. Omnivincible was assembled by Angstrom Levy to help start the Invincible War in the mainstream dimension. After the war, he and the surviving variants turned on Angstrom for breaking their deal and were subsequently banished to the Wasteland Universe.

Alternate version of Mark Grayson

Karen O'Malley is a high ranking individual in the Human Resistance on Counter-Earth.

From the Unlimited Tv Show

Briefers "Brief" Rock (ブリーファス・ロック / ブリーフ, transliterated as "Burīfasu Rokku" / "Burīfu") is the tritagonist of Panty & Stocking with Garterbelt. He is a self-proclaimed ghost hunter and irrevocably in love with Panty.

Awkward ghost hunter geek boy

Polyester (ポリエステル Poriesuteru) is an antagonist in New PANTY & STOCKING with GARTERBELT. He is one of two angel brothers sent from Heaven, and is the older brother of Polyurethane. Polyurethane (ポリウレタン Poriuretan) is an antagonistic character in New PANTY & STOCKING with GARTERBELT. He is an angel sent from Heaven, and is Polyester's younger brother. He debuted in "The Brothers from Heaven".

Polyester and Polyurethane from Panty and Stocking

Circe was a divine sorceress. She was banished to Tartarus by Hippolyta for transforming innocent people into animals.

She doesn't experience jealousy, and once a relationship ends - at least romantic - she either moves on or realises that there weren't significant romantic feelings to begin with, thus moves on easier. She even encourages Clark to commit himself to Lois by revealing his secret identity, since she sees that he loves her deeply, yet holds back out of fear, thus Diana, wanting the best for her friend, continues to gently push him. She has a lack of jealousy, but it may blind her.

From the DCAMU

Kitten is the daughter of the villain Killer Moth and the girlfriend of the mutant Fang. Bratty, bossy and spoiled, she is perhaps the only person her father ever knuckles under.

From Teen Titans

Kara Zor-El, also known as Supergirl and formerly known as The Kryptonian Warrior, is one of the two tritagonists (alongside Jimmy Olsen) of the 2023 superhero cartoon series My Adventures with Superman.

From My Adventures With Super-Man

Galatea, also known as Tea,[1] was Supergirl's clone and Cadmus's product/asset.

From The DCAU

Superwoman is the evil counterpart of Mary Marvel and Wonder Woman.

Wonder Woman’s Evil Counterpart 

Margaret Connors was the wife of Doctor Curt Connors and mother to their young son Billy.

From the 90’s series

Maybelle "May" Parker (also known as Aunt May and simply May) is a character who appears in the Marvel Comics animated series Your Friendly Neighborhood Spider-Man. This universe is set in 2015, in an alternate universe of the main Marvel Cinematic Universe, when her nephew first starts out as Spider-Man.

From the YFNSM series

The Imagined was a chaotic member of The Seven introduced in Chapter 3: Season 2. She was one of The Sisters first mentioned by The Foundation during Zero Crisis Finale. She was the daughter of Geno, genetically changed to be "perfect" in her father’s vision. She possibly lied to The Looper saying she had no recollection of her past.

An Arrogant War Hero

Gwendolyn Stacy is friends with Peter Parker and Harry Osborn. She is the daughter of New York City Police Department captain George Stacy. Despite romantic feelings between her and Peter, she dated Harry when he began dating Liz Allan.

From the Spectacular series 

Baby Doll is a recurring antagonist on the T.V. series Kite Man: Hell Yeah!
She is a criminal and the current manager of a Villigan's, who was born with a disorder that prevents her from outwardly growing into an adult.

From the Kite Man tv series 

Sally Avril is Randy "Rand" Robertson's shrill-voiced girlfriend.

From the spectacular series 

Martha Connors is the wife of Curt Connors.

From the spectacular series

Liz Allan is a high school student and cheerleader.

One of Doctor Strangefate's aides, Wanda Zatara uses her metamutant-based mystical energies to atone for the misdeeds of her father. Many men fell victim to her combination of magic and seduction.

From the Amalgamation Universe

Barbara Gordon was the daughter of Gotham City Police Commissioner, James Gordon. She took on the mantle of Batgirl, Batman's partner and protegé for many years. Later in life, after leaving behind her costumed persona, Barbara followed in her father's footsteps by becoming the Commissioner of the Gotham Police Department herself.

Liz Allan is a college student and good friend to Mary Jane Watson, Peter Parker, and Harry Osborn.

Gwendolyn Maxine "Gwen" Stacy, also known by her superhero alias Spider-Woman, is the deuteragonist of Sony Pictures Animation‘s Spider-Verse film trilogy. She is an alternate version of Gwen Stacy who got bitten by a radioactive spider and took on the mantle of Spider-Woman. In the original film, she was sent to an alternate dimension where alongside an alternate version of her best friend Peter and that universe's native Spider-Man Miles Morales attempted to travel back and stop crime lord.

From ITSV & ATSV

Silk (real name Cindy Moon) is a fictional character and superheroine appearing in American comic books published by Marvel Comics, appearing as a supporting character in the Spider-Man comics, and the main protagonist in her titular comics.

From the comics 

Mayday Parker, a.k.a. Spider-Girl, is a Marvel Comics superheroine and the daughter of Peter Parker and Mary Jane Watson in the MC2 universe.

From Earth-982

Anna-May "Annie" Parker (of Earth-18119), better known as her super-heroine alter-ego AMP later Spiderling, is the daughter of Spider-Man (Peter Parker) and Mary Jane Watson.

From the comics

Vanna Smith is a minor character in the Spider-Man comics. Since Spider-Man was always saving her, she assumed that he had romantic feelings for her, and was even staging some of his battles just to impress her. Her paranoia of him made her think that Spider-Man was a peeping tom that was harassing her. In reality, Spider-Man was just being a hero.

Olga is a Russian woman who was married to the superhero Red Rush before his death at the hands of Omni-Man.

From Invincible

Jessica Drew (of Earth-1610) is a female clone of Peter Parker whose chromosomes were manipulated to make her female. She resembles Peter, and appears to be the same age (approximately sixteen).

Flora Latour is a blue pixie from Sonic Underground, and Tamers12345's Youtube channel. She is the adopted daughter of Mark Latour, and the adoptive sibling of Mindy Latour and Mandy Latour.

From Tamers12345

Amanda, better known by her superhero alias Monster Girl, is a major character in Invincible, debuting from Season 1. Formerly known as Monster Woman.

De-Aging Superhero from Invincible

Elizabeth "Betty" Brant is a supporting character in the animated series The Spectacular Spider-Man. She is the 20-year-old assistant of J. Jonah Jameson at The Daily Bugle. She is a woman who Peter Parker had a crush on and is the girlfriend of Ned Lee (The show's adaptation of Ned Leeds).

May Parker is the widow of Ben Parker and surrogate mother of Peter Parker, the first Spider-Man.

From the Ultimate comic series

Dr. Pamela Lillian[1] Isley was a botanist who led a secret life as the eco-terrorist Poison Ivy. Unlike most of Batman's rogues, she had little interest in money or power unless she needed them, instead being obsessed with preserving plant life and taking revenge on those who she believed had harmed it. Her ruthless methods frequently landed her in Arkham Asylum.

Diana Prince, aka Wonder Woman is one the main protagonists of the DC Animated Universe, and a founding member of the Justice League.

Poison Ivy (real name: Dr. Pamela Lillian Isley) is a major antagonist in the DC Animated Universe. Dr. Harleen Quinzel, known more commonly as Harley Quinn, is a major antagonist in the DC Animated Universe. Leslie Willis, also known as Livewire, is a major antagonist in Superman: The Animated Series and a minor antagonist in The New Batman Adventures, Justice League, and Justice League: Unlimited. She is an electrokinetic supervillain and an enemy of Superman.

From the DC Animated Series’s

Zatanna Zatara was a magician and stage performer with real magical powers and a close friend and ally of Batman, who joined the expanded Justice League after the Thanagarian invasion.

Dinosaurus is a major antagonist in the Invincible franchise. He is a split personality from his human counterpart David Anders. While his past as Anders is unknown, Dinosaurus is a highly intelligent dissociative personality that is primarily focused on trying to help humanity with highly destructive goals.

From Invincible 

Jessica Miriam "Jess" Drew, also known as Spider-Woman, is a fictional character and superheroine in Marvel comics. She is the first Spider-Woman in the Marvel Universe, an ally of Spider-Man and his numerous spider allies, and member of the Avengers, Lady Liberators, and Daughters of Liberty.

May Parker is the loving aunt of Peter Parker and the widowed wife of Ben Parker.

From the 90’s series 

Samantha Eve Wilkins, also known as Atom Eve, is a superhero who is capable of transforming matter into anything she desires. She serves as one of the main protagonists in Invincible.