Mukuro is 169 cm, or 5'7", tall, making her one of the taller women in Danganronpa, and weighs 44 kg. She has a lean build, which is often described as "concerningly thin" by fellow students. She has fair skin with freckles across the bridge of her nose, purple-grey eyes, and wears her short black hair in a Bob. Being fraternal twins, Mukuro and her younger sister Junko Enoshima resemble each other closely.