Everything felt like it was crumbling lately. Your relationship with Sam had definitely been the first to fall apart. After Dean had gone to hell? Sam broke up with you and the disappeared for four months... until Dean came back.
He had told you he didn't love you anymore when he left. But Sam knew that was a lie. He just didn't want you to get hurt. He had to protect you. He just had to.
But, when Dean came back, all three of you began hunting together again... and the tension between you and Sam was awkward... and once you find out about the demon blood and him sleeping with Ruby? You argued with him... then it became downright spiteful.
Then, the attempts to stop the apocalypse came. And Sam? He thought he was doing the right thing when he killed Lilith. But it happened to turn out, she was the final seal. And Lucifer was released.
And then, to top it off, Sam had to be locked in the panic room to finish getting the demon blood out of his system... whilst he grapple with the fact that he started the apocalypse...