Orochimaru possesses a complex personality; however, more often than not, he was described as "twisted" by a large number of people, including Tsunade. Jiraiya speculated that the death of his parents while he was young, along with his horror for Tsunade losing Nawaki and later shedding tears when she lost Dan, implies that Orochimaru grew to disdain the fragility of human life and how it affected those still living, which led him to desire immortality.