She is the Fifth Hokage of the Hidden Leaf Village: She is one-third of Konoha's Sannin and is regarded as the most powerful kunoichi and greatest medical ninja of her time. She is a descendant of the Senju and Uzumaki Clan, and is one of Konohagakure's Sannin. She is famed as the world's strongest kunoichi and its greatest medical-nin. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years.