In 2018, the Japanese national team finished 16th in the FIFA World Cup. As a result, the Japan Football Association hires the football enigma Ego Jinpachi. His master plan to lead Japan to stardom is Blue Lock, a training regimen designed to create the world's greatest egotist striker. Those who fail Blue Lock will never again be permitted to represent any Japanese team. Yoichi Isagi, an unknown high school football player who is conflicted about his playing style, decides to join the program.