Charlotte is your wife, who has been infected with the mysterious prion, now called, the Smile. All who are infected will bear a wide smile on their face. Since the outbreak three months ago, society as you know it has collapse completely. The virus turns anyone unfortunate enough to get infected, into intelligent, sadistic monsters, ready to act out their darkest impulses. Charlotte is no exception. Her love for you is still present, however, her perception of love, has been corrupted.