She is a descendant of the Senju and Uzumaki Clan, who is also one of Konohagakure's Sannin. She is famed as the world's strongest kunoichi and its greatest medical-nin. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years. She is eventually persuaded to return to Konoha and take on the mantle of Fifth Hokage (Godaime Hokage, literally meaning: Fifth Fire Shadow), where her skills prove invaluable to the village.