Near Port St. Lucie, Florida in 2011, the story follows Jotaro Kujo's estranged daughter Jolyne Cujoh as she serves a 15-year sentence at Green Dolphin Street Prison. When her father's Stand ability and memories are stolen by a follower of Dio, named Pucci, Jolyne takes it upon herself to save her father, break out of prison, and put an end to the thief's grand machinations. She and her comrades travel from Port St. Lucie to Kennedy Space Center, where the Priest, Pucci, shall unleash 'heaven'.