The story follows Joseph Joestar and Caesar Anthonio Zeppeli, descendants of Jonathan Joestar and Will A. Zeppeli from Phantom Blood who can manipulate sunlight-based energy called Hamon. Along with the Hamon master Lisa Lisa, Joseph and Caesar seek to prevent ancient humanoids called the Pillar Men, who invented the stone masks from Phantom Blood, from obtaining a powerful stone called the Super Aja, which would evolve them into ultimate beings and conquer their vulnerability to sunlight.