Tsunade Senju is the Fifth Hokage of Konohagakure. As a direct descendant of both the Senju and Uzumaki clans, she possesses a unique combination of their powerful attributes. Her mastery of medical ninjutsu is unparalleled, and she is known for her immense physical strength, which allows her to perform feats such as splitting the ground with a single finger. Tsunade is also credited with revolutionizing the medical ninja system by establishing strict guidelines for medics on the battlefield.