Rena is a signature character as she is featured more than once during the first anime season-opening, as well as appearing on most of the album and game covers. She appears in much of Higurashi's official art and even serves as something of a mascot for 07th Expansion. 

✽ Clever Girl

Shiki Tohno (遠野 志貴, Tōno Shiki?) is a member of the Tohno household living in Misaki Town. He possesses the Mystic Eyes of Death Perception, Mystic Eyes that allow him to see "death." He is the main protagonist of Tsukihime and the Tsukihime series. 

• God of Older Brothers

Sonozaki Shion (園崎 詩音) is one of the main characters in the Higurashi no Naku Koro ni series, Sonozaki Mion's twin sister, and the antagonist of the question arc Watanagashi-hen and the protagonist of its answer arc Meakashi-hen. She is well known for her spectacular mental breakdown and the ensuing bloodbath in those arcs, her mischievous nature when it comes to teasing the other club members, as well as for her relationship with Hōjō Satoshi.

⍉ Shii-chan

Sonozaki Mion (園崎 魅音) is one of the main characters in the Higurashi no Naku Koro ni series, Sonozaki Shion's twin sister, and the heir of the Sonozaki house. Mion is the more well-known sister of the Sonozaki twins, as well as the more mature, stable, and tomboyish one. Her and her sister's age are implied to be 14.

⌨ Mii-chan

Hinamizawa (雛見沢) is a fictional village (雛見沢村・Hinamizawamura) and the main setting for the Higurashi no Naku Koro ni series. It is located in the Shishibone City, adjacent to Gifu Prefecture where its inspiration exists. The village becomes known for carrying the unusual fictional disease called the Hinamizawa Syndrome. 

☒ Also known as, Onigafuchi

Takano Miyo is a nurse at the Irie Clinic. She is one of the consistent victims of the curse in 1983. According to the police, her charred remains are found in a drum in the mountains; however, the autopsy later reveals that she had died twenty-four hours before the Watanagashi Festival had even occurred. During Tatarigoroshi-hen, she gives Maebara Keiichi a ride after he finishes his business with Satoko's uncle, and the subsequent revelation of her "death" prior to this incident shocks him.

ꕤ Rose Guns Days

Nemu Manaka (真中 合歓) is one of euphoria's heroines. A second-year at Rokukeikan Academy, she is Keisuke's classmate and considered to be the most beautiful girl in his class. She's always by herself in class and despite being classmates with Keisuke and Kanae, she has hardly interacted with them. 

⌰ Sleeping Beauty

Maebara Keiichi (前原 圭一) is one of the protagonists in the Higurashi no Naku Koro ni series. He serves as the protagonist of four Question Arcs: Onikakushi-hen; Watanagashi-hen; Tatarigoroshi-hen; and Taraimawashi-hen. He is a very sociable, charismatic boy with a lively attitude, and his talented tongue allows him to fit in the town quickly and make new friends. While his exact age is never explicitly stated, he is implied to be 14/15.

❆ Magician of Words

Furude Hanyu is a goddess that appears in Minagoroshi-hen and beyond. Hanyū's past is shrouded in mystery, but she has referred to herself as a demon who became a goddess after she was sacrificed at a true Watanagashi ceremony centuries past to atone for the sins of others. She is also the mother of Furude Ōka and the wife of Furude Riku. She is also known as Oyashiro-sama. 

☽ Oyashiro-sama

Lambdadelta (ラムダデルタ Ramudaderuta) is the Witch of Certainty and Beatrice's sponsor who has come to observe her game. She first appears in Turn of the Golden Witch.

ও Witch of Certainty

Hojo is the younger sister of Hōjō Satoshi and the insinuator of the events that take place in Tatarigoroshi-hen, Tsukiotoshin-hen, and, to an extent, Minagoroshi-hen. She is also the protagonist of Yakusamashi-hen, Satokowashi-hen and the main antagonist of Higurashi no Naku Koro ni Gō and Sotsu.

⚸ Trapmaster

Furude Rika (古手 梨花) is ultimately the true main protagonist of the Higurashi no Naku Koro ni series. She is the daughter of the late shinto priest of Hinamizawa. She is the current miko/kannushi, or shrine maiden/priestess, of the Furude Shrine, appearing in miko garb for her part of the Watanagashi Festival. She appears as the protagonist of Minagoroshi-hen. 

㊊ ''R''

Bernasktel is the Witch of the Fragments, who has lived for a thousand years.

It is said she lives in a world where the concepts of fate and possibilities can be visualized.
She observes the fate of humans and sometimes interferes.

In other words, sometimes she is you, and sometimes she is your only friend. ...Understand?

She likes wine and spicy foods.
She hates boredom, happiness and people who never learn. 

月 Witch of Miracles

Blackfire (real name Komand'r) is the firstborn eldest daughter and princess of the long-dead King and Queen of Tamaran and the older sister of Starfire and Wildfire. She is the former Grand Ruler/Empress of Tamaran and serves as Starfire's arch-nemesis and an enemy of the Teen Titans. 

✫ Former Empress of Tamaran

A woman with horns not unlike Hanyuu's. Calls Rika her "cat". Awards Satoko with the power to live in loops to provide her with entertainment. Satoko calls her "Eua", but her true name and nature are unknown.