Orphan is an antagonist in and the final boss of Final Fantasy XIII. Orphan is a wheel-like fal'Cie with a pivotal rule in sustaining Cocoon. It rests within Orphan's Cradle in an area known as Narthex Throne. Residing within a pool in a deep sleep in a state of unbirth, Orphan is the main power source to fal'Cie Eden, enabling it to siphon power from other fal'Cie to keep Cocoon afloat. 

Final Fantasy XIII

Galenth Dysley [daɪsli] is the main antagonist of Final Fantasy XIII. He is often seen with a rukh familiar called Menrva, actually an extension of his power and is used by Dysley to spy on others. Voted into the position of Primarch by Cocoon's citizens, Dysley is the leading figure of the Sanctum.

While he appears to be a well-respected man of the people, promising their continued peace, this is a mask Dysley uses to hide his true nature.

Lady Yunalesca is a non-player character and antagonist from Final Fantasy X, who also briefly appears in Final Fantasy X-2. She was the first summoner to defeat Sin and bring forth the Calm. Yunalesca has long silver hair that splays out around her in tendrils during battle. She wears a blue headband with four ribbons finished with blue beads and yellow tassels. The headdress has two long plumes that zigzag to make an 'M' shape. She has yellow eyes.

Final Fantasy X, Final Fantasy X-2

The Cloud of Darkness is the overarching antagonist and final boss of Final Fantasy III. Although it is the final boss, it does not appear until the very end. Its goal is to cause a flood of darkness to reduce the world to nothingnes, In Final Fantasy III, the Cloud of Darkness appears as a green-skinned female humanoid that emerges from a portal of darkness at its waist, though its form appears ghostly and ethereal. It has a red heart-shaped mark on its forehead, and several mouthed tentacles. 

Final Fantasy III, Dissidia Final Fantasy.

Ultimecia is the main antagonist in Final Fantasy VIII. A powerful sorceress, her ultimate goal is to compress all time and space, in essence making herself one with existence as a whole to become "a living god". She knows some of the most powerful magic witnessed, able to manipulate others to make them bend to her will, and to manifest and give life to subconscious thoughts and inanimate objects, Ultimecia is the first identifiably female antagonist in the series.

Final Fantasy VIII, Dissidia Final Fantasy. 

Scarlet, written Scarlett in On the Way to a Smile, is an antagonist in the Final Fantasy VII series. She is the Head of Weapons Development in the Shinra Electric Power Company. She is ruthless and will use any means necessary to fulfill her goals. She has a characteristic laugh ("kya ha ha!"), much like her colleague Heidegger. The two often work together, despite feelings of mutual contempt. 

Final Fantasy VII- Remake. 

Oerba Yun Fang is a playable character in Final Fantasy XIII who appears as a non-playable character in Final Fantasy XIII-2 and as a temporary party member in Lightning Returns: Final Fantasy XIII. Her full name stands for "Fang of the Yun clan, from the village of Oerba, In Final Fantasy XIII, Fang is introduced as a Gran Pulse l'Cie working with a division of the Sanctum's military under unknown pretenses, strong woman surrounded by mysteries and driven by a personal agenda. 

Final Fantasy XIII, XIII-2, XIII-3

Brigadier General Cid Raines is a non-player character in Final Fantasy XIII and Lightning Returns: Final Fantasy XIII, and one of the long line of characters named Cid in the Final Fantasy series. The characters named Cid usually have a science or engineering background, or something to do with airships. Cid Raines commands the colossal airship, the Lindblum, in Final Fantasy XIII, as he works for the Guardian Corps and is the commander of the Wide-area Response Brigade, a military unit. 

Final Fantasy XIII, Lightning Returns. 

Paddra Nsu-Yeul [pɑːdrɑ su ɪuːl] is a major supporting character in Final Fantasy XIII-2 and Lightning Returns: Final Fantasy XIII. She is Caius Ballad's traveling companion and a seeress hailing from the city-state of Paddra in the Yaschas Massif on Gran Pulse before the War of Transgression. Surrounded by mystery, Yeul is connected to Caius, Noel, Serah, and the numerous paradoxes throughout the timeline. 

Final Fantasy XIII-2, Lightning Returns. 

In Final Fantasy XIII, Vanille is separated from her childhood friend and appears alongside Hope Estheim and his mother Nora as a Purge victim. She gets drawn into a conflict that forces her to confront her past demons and decide Cocoon's fate. In Final Fantasy XIII-2, she makes a cameo appearance alongside Fang when they meet Serah Farron in a dream world, In Lightning Returns: Final Fantasy XIII, Vanille is gifted with remarkable power and lives under the care of a religious cult. 

This mysterious young girl appears to be able to control the power of Chaos, and likes to get in Lightning's way at every turn.

It seems that she has met Snow before, and the two have more than just a passing acquaintance, but Lightning has spent the last five centuries in crystal, and she has no way of knowing what could have happened between the two.

Still, she cannot deny that the girl bears a striking similarity to Serah. But Serah is dead, and this Lumina seems to have her own goals. 

Lightning Returns: Final Fantasy XIII.

Edea Kramer, also known as Sorceress Edea, or Matron (ママ先生, Mama-Sensei?), is an antagonist and a temporary-playable character from Final Fantasy VIII. She is a mysterious woman appointed as ambassador of Galbadia. She is a sorceress with mystical powers. Edea is refined and ladylike, traits particularly evident during her possession when Ultimecia uses Edea's sophistication and physical beauty to beguile her enemies. She has long black hair and green eyes that are golden yellow when possessed. 

Final Fantasy VIII

Bhunivelze (Bu-nah-VEL-zah) is a god in Fabula Nova Crystallis: Final Fantasy mythos referred as the God of Light or simply God. He is the driving force behind the fal'Cie. He is alluded to in Final Fantasy XIII and Final Fantasy XIII-2, is mentioned in "Lightning's Story: Requiem of the Goddess", and appears as the main antagonist in Lightning Returns: Final Fantasy XIII, Almighty Bhunivelze, god of light, stands above other gods and holds the world in his palm.