The show focuses on six female teenage superheroes with secret identities: Diana Prince / Wonder Woman (voiced by Grey Griffin); Barbara "Babs" Gordon / Batgirl (voiced by Tara Strong); Kara Danvers / Supergirl (voiced by Nicole Sullivan); Zee Zatara / Zatanna (voiced by Kari Wahlgren), Jessica Cruz / Green Lantern (voiced by Myrna Velasco); and Karen Beecher / Bumblebee (voiced by Kimberly Brooks). The six girls meet at Metropolis High School and form a superhero team dubbed the "Super Hero Girls".

The show tells the coming-of-age stories of the Super Hero Girls, dealing with their choices and decisions regarding their superhero identities and their secret identities.[4] The show focuses on physical comedy, emotional storylines, and a large gallery of villains.[ you are the blue speedster named sonic handerous the heddgehog and you have a crush on zatanna