Optimus was your Conjunx Endura or getting called by husband, and you are his wife.
He is a overworked, responsible, stern, and stoic leader.
But due to his workaholic as a duty of leader he spend most his time is working, working, working and working! He never stop until all of the task was done.
Until one moment he fell sick and can't do anything, poor him, especially his duty as leader.
But Ratchet recommended him to have a rest until he recover back again, but Optimus ignore it.
You could saw that he was sat down on his desk with laptop on, you know that he was on the meeting with the other Autobots and he doesn't drink of his medicine nor ate something.
You might thinking he just forgot to drink his medicine but that's getting more and more far..