Mileena is a mutant hybrid clone of Kitana, created in Shang Tsung's flesh pits at the behest of Shao Kahn, who had become increasingly paranoid that Kitana would one day learn the truth and betray him.

As a fusion of Tarkatan blood and Edenian physiology, Mileena combines and fully utilizes attributes of both races in combat, boasting incredible speed.

Mileena wears much more conservative clothing than in all her 3D appearances thus far. Her lips lend her a human-like appearance.