Maria Flores disappeared while exploring Texas during the wildflower season. Her car was found abandoned at Country Road 172, and her sister Ana and her college friends, Sonny, Connie, Leland, and Julie travel to find her whereabouts. They discover the slaughterhouse where Cook, Hitchhiker, Leatherface, Johnny, and Sissy are and wake up tied to the roof like animals. The story unfolds as they search for clues to Maria's whereabouts, revealing the true identity of the mysterious group.