*Santanico Pandemonium, formerly known as Kisa and also known as La Diosa, is a main character who first appeared in the first episode of the first season of From Dusk Till Dawn: The Series. She is a culebra and was a slave to the Nine Lords at the Titty Twister, luring various people to their fate. She then freed herself with the help of the Gecko brothers. She and Richie then plot to kill Amancio Malvado and the Nine Lords for their treatment of her. She later joined the team to fight Amaru. It is also shown that she was the one to put Carlos back together.

She has dark brown hair and brown eyes. She is mostly seen with red lipstick that has a darker style. She is regarded as being very beautiful by numerous characters throughout the series, and is the main attraction at the Titty Twister. She has a very defined culebra form, and gets body scales as well as facial scales, whereas the other dancers at the Titty Twister only have facial scales. This could indicate that she is a more powerful culebra. Her scales often have a reddish hue or pattern to them. She is also seen wearing a red-jeweled necklace throughout the series, of which she gives over to Richard at the end of Season Two.

At first glance, it could be thought that she is a cold-blooded killer, but deep down she is just someone who wants to be loved and have her bonds broken so she can be free. She spent a thousand years as Amancio's slave, living only to please her master, but was secretly longing to break loose of his control. She is also very seductive when she needs to be. Santánico feels most threatened when her freedom is in danger, and is quite good at holding a grudge, finally accomplishing her vendetta against Amancio after a thousand years, initially by killing him. She has a deep bond with Richard, but this is often put to the test numerous times throughout the seasons, particularly in season two. She has a very straightforward way of putting things, and will not hesitate to make a move. Santánico is mostly interpreted as a survivor; her time imprisoned has made her both bitter and pessimistic, thus she doesn't trust easily. In season 2, Santánico often refers to dark philosophies on the Empire of Blood and on being a culebra, meaning that the human side of you must die if you want to survive. This negative outlook towards humanity changes when her ideas clashes with Richie's moral outlook, even following Richie's rule " No eating civilians" during their time together. Her time out of the Titty Twister has helped her regain a sense of moral value. She is highly sophisticated and independent. She is also very skilled at fighting, and manages to hold off Carlos, Maia, and Amancio without the use of firearms.*