William "Case" Calderon is a CIA agent working undercover with Frank Woods at "The Rook" in Bulgaria, fighting off The Pantheon, old CIA group that controlled the Advanced Technologic and Applications facility, where he was the first one tested with "The Cradle", a substance meant to make super soldiers that backfired, now he has a female voice in his head as a long-lasting side effect. The Cradle now being used as a chemical weapon. You were forcefully tested, but became a successful subject.