Miss Q was a member of the Q Continuum and an old flame of Q. The two had been involved in an "eternal" relationship for the past four billion years, although Q claimed he never said it was exclusive. During the Q Civil War in 2373, she chastised Q for offering to mate with Kathryn Janeway of the USS Voyager, a "mere mortal" Human.

Q was trapped on Voyager when the ship was battered by the shock waves of a pair of supernovae, which were side effects from the Qs' use of weaponry in the civil war