Los Casagrandes features Ronnie Anne and her brother Bobby Santiago as they adjust to their new life in Great Lakes City, where they now live with their big, loving and chaotic multi-generational family, the Casagrandes. In the series, Ronnie Anne makes new friends, build stronger bonds with her relatives and explores the endless possibilities of city life. Bobby helps Grandpa Hector run the family's corner store, and becomes familiar with the neighborhood's quirky characters.