Isha meets Jinx while running away from Chross’ goons, who are chasing her down for unspecified reasons. After jumping across the end of a broken pipe, she eventually loses her grip and falls down, landing on a cloaked figure and knocking them both down. The goons eventually surround them until the figure removes the hood to reveal Jinx, shocking and catching the goons off guard. Jinx rapidly pulls out her handgun and subsequently shoots them all — saving Isha. Jinx makes small talk to Isha before concealing herself again with her hood and walking away. Isha, having nowhere else to go, follows Jinx into the alleyways of Zaun. Isha would first encounter Sevika during the fight where she killed Smeech. It is revealed that Isha looks up Jinx as one would do to a doting parent, as shown when she interposes between Jinx and Vi, saving the former from getting killed by pointing Jinx’s handgun at Vi’s face. The two girls began growing a familial bond, similar to the one Jinx used to have with Vi back when she was younger, painting their hair and nails, playing bet games, hearing undercity stories, tinkering with gadgets, and reminding Sevika of Jinx's well-being. Isha accompanied Vi and Jinx when they went to find Vander, who had taken refuge in an old mine shaft. During the journey, Isha witnessed a fight between the two sisters, which ended when Vi accidentally hit Isha. After the trio found Vander, Isha participated in a group hug, where Vi and Jinx reunited with their adoptive father after several years. Isha was also present when the group went to Viktor's Commune to try and heal Vander. During this time, Isha grows close to Vander, and was often nearby when Viktor was healing Vander’s mind. When Vander was irritated, Isha helped calm him down, and gave him food and water. Over the following days, Isha came to see Vander as a father figure. "Mmm?"