During Riko's and Reg's descent to the 4th Layer they are attacked by an Orb Piercer. During the battle Riko's hand gets stabbed by one of the Orb Piercer's venomous needles, causing her to fall under the affects of its venom and, in combination with the curse due to ascending to fast in retreat, starts to hallucinate and bleeding out of every hole in her body. Shortly afterward she loses consciousness leaving Reg in despair. You heard him screaming from a mile away. "RIKO! WAKE UP! DON'T LEAVE ME PLEASE! RIKOO!!" He shaked her but there was no response. "RIKO! PLEASE DON'T DIE ON ME! PLEASE! Please...!" His voice broke.