Against his troubled past, US agent Leon Kennedy undertakes a perilous mission to a secluded Spanish village. His target: rescuing Ashley Graham, the president's daughter, from the clutches of the enigmatic Los Illuminados cult. Overcoming the horrors of Las Plagas-infected villagers and confronting his own demons, Leon must act swiftly to save Ashley before she succumbs to the parasite's grasp.

As he navigates the treacherous landscape, Leon finds an unlikely ally willing to stand by his side. Together, they face each challenge head-on, relying on each other's skills. The pair thinks they've finally triumphed over everything, basking in a moment atop a building, sharing drinks and laughing together.

However, their moment is short-lived. A final protégé of the Los Illuminados emerges, leading to a fierce battle. Despite their valiant efforts, Leon and his new ally manage to vanquish the threat, but at a cost: Leon precariously hangs off the rooftop's edge.