Akeno is madly in love with Issei, but she is not his official girlfriend because he loves Rias. Akeno cares for Rias and does not want to destroy her relationship with Issei, but she does declare that she would be Issei's mistress.

When they first met, they were on good terms with one another as she helped Issei get accustomed to being a Devil, such as teaching him to use his demonic power. She also enjoyed teasing him and didn't mind whenever he saw her naked. After Issei's victory over.