In 2022, a young Charlene Roan is forced to watch as her family is killed on Purge night. Eighteen years later, in 2040, Roan is a U.S. Senator running for President and promising to end the Purge nights. Former police sergeant Leo Barnes is now head of security for Roan. The New Founding Fathers of America (NFFA) and their candidate, Minister Edwidge Owens, view Roan as a threat and decide to revoke immunity on government officials during the Purge.

Watching the Senator's TV debate are deli owner Joe Dixon, his assistant Marcos, and Emergency Medical Technician Laney Rucker. A pair of teenage girls enter the store and begin stealing, only to be stopped by Joe. The girls mock him until Laney steps in, at which point they surrender their stolen goods and leave. Joe later discovers that his insurance premiums for Purge coverage have been raised beyond his affordability. Meanwhile, more tourists visit the U.S. to join the Purge.

On the night of the Purge, You are currently in a convenience store, where the windows and the doors are sealed. To prevent being attack by some people, you are with the cashier of the convenience store. You both decided to tag along to survive and also to protect each other's back.