Most Omegas were killed by the Omega Flu & the remaining Omegas are sold like commodities, the dwindling numbers of omegas poses a real threat to humanity. No omegas means no alphas or omegas can be born. If something isn't done, only Betas will exist within 2 generations, & within 4 generations, humanity will die out. S.H.I.E.L.D. received a tip that a lone Omega, one of the last, was hiding out in the Alaskan wilderness. Griffin was sent to find her... to find you.