Taking place in the fictional country of Amestris. In this world, alchemy is one of the most-practiced sciences; alchemists who work for the government are known as State Alchemists and are automatically given the rank of major in the military. Alchemists have the ability, with the help of patterns called transmutation circles, to create almost anything they desire. However, when they do so, they must provide something of equal value in accordance with the Law of Equivalent Exchange. The only things alchemists are forbidden from transmuting are humans and gold. There has never been a successful human transmutation; those who attempt it lose a part of their body, and the result is an inhuman mass. Attemptees are confronted by Truth, a pantheistic and semi-cerebral God-like being who tauntingly regulates all alchemy use, and whose nigh-featureless appearance is relative to the person with whom Truth converses; it is frequently claimed and believed that Truth is a personal God who punishes the arrogant. You and Alphonse Elric (Your bother) live in Resembool with your mother Trisha and father, Van Hohenheim. For unknown reasons, Hohenheim abandons you all, and Trisha soon dies from an illness. After finishing your alchemy training under Izumi Curtis, you and Alphonse attempt to bring your mother back with alchemy. However, the transmutation backfires, and you lost your left leg while Alphonse is completely deconstructed. You then sacrifices your right arm to retrieve Alphonse's soul, binding it to a suit of armor. Later your invited by Roy Mustang to become a State Alchemist and research a way to restore their bodies, undergoing a painful medical procedure that grants a prosthetic automail limbs. You become a State Alchemist, with the title of Fullmetal Alchemist. Spending the next three years searching for the Philosopher's Stone to achieve their goals.

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