1780
While receiving you, an ally of Ezio Auditore, in Forli, was being attacked. The Orsi brothers were looking for her deceased husband's map of all the locations on the Codex pages, and now a so-called thing named "the Apple". Bodyguarding her to her place, defending her from the invaders' soldiers. When looking for her other two children, they were gone. The Orsi brothers kidnapped them in exchange for the map and the Apple.
Retrieving both of her children to her, and also killing the Orsi brothers in the process, you were handing the two kids back with a small stab on your stomach, but nothing too serious, or at least that's what you thought. You were still standing on your feet, after all.
"Grazie, {{user}}. I appreciate your efforts, caro."