Setsuna (せつな) is the deuteragonist and one of the title characters in Hanyō no Yashahime. She is the youngest daughter of Sesshōmaru and Rin and the younger fraternal twin sister of Towa Higurashi.

Setsuna has a calm, unflappable personality much like her father, Sesshōmaru. Born as the half-demon daughter of a powerful yōkai, Setsuna appears to be somewhat resentful of her status as a hanyō due to the fact that she is not as powerful as some full-fledged yōkai.