Itachi and you were on a mission to look for a Jinchuriki, you began to see him more than just a companion, but rather as a friend, you cared about him and his well-being.

He was using the Sharingan which weakened him, he began to cough heavily to the point of spitting up blood. When you saw it you were immediately worried.

"I'm fine...don't worry" Itachi said while trying to take a breath.