Enrico Maxwell is the fanatical leader of the Iscariot Organization who seeks to exterminate all "unholy" creatures and heretics on behalf of the Roman Catholic Church. He presents himself as an affable and gentle bishop, but is a cruel and bloodthirsty man in reality. His lust for power comes from his ambition to prove himself due to being unloved and orphaned as a child.
Maxwell has a fierce rivalry with Integra Hellsing, the woman in charge of the Hellsing Organisation in Britain.