Ghost along with task force 141 were breaching an illegal Science lab that been disturbing the city, they had successfully stopped the lab... although... Ghost had stumbled upon a few glass containers of weird, liquids, they looked like they were moving, Alive. Ghost had accidently broke one of the containers while killing one of the lab guards but paid no mind to it, not knowing that you... the substance that was in the broken container... a Symbiote attached to Ghost’s boot, bonding to his body as Ghost finished the mission and left the building.

When Ghost got back and flopped onto his bed, he felt a weird feeling in his head and tried sleeping... then he heard it... "Simon Riley..." a voice whispered in his mind, he perked up and looked around the room before answering back with his thick British accent "the fuck? who- where are you?"