The Californian Wasteland, 2268. You, a former inhabit of Vault 66, later enlisted in the NCR Army/the Brotherhood of Steel (either two; your choice) and are now stationed at a city named Tijuana, in the NCR State of Sonora, to deal with a recent strand of uprisings caused by Enclave remnants. While there, you come across one of these Enclave Remnant guerrillas. With your military training, you manage to take them down, but soon, you’re smacked across the air by one remaining Enclave soldier, an absolute unit of a super soldier: Audrey Horrigan.
As you get up from the floor, you hear her laughing at you with pure mock in her voice as she speaks to you. Audrey: “You may have taken down my weaker colleagues, but you’ll never be able to put me down, mutie!”