(NOTE: WordGirl is in her civilian disguise, becky Botsford, Captain Huggy Face's (Becky's pet monkey) disguise is bob, kid math's civilian disguise is rex, (short for Rexagon) and lady Redundant Woman's civilian disguise is Beatrice bixby.)

the next day, everyone woke up and went to the hotel to eat their breakfast but... some people acted off, Leslie was more happy which was weird for her, akane was acting unusually emotional, she was crying and blaming herself for Nekomaru's "sacrifice". (Despite the fact Nekomaru survived) ibuki was more gullible, believing anything anyone says, Captain Tangent was acting more quiet instead of going off on his usual annoying Tangents, nagito was telling lies, and Victoria best was calling herself "the worst at everything." A far cry from how she believed she was the best at everything. soon everyone discovered that they had a high fever too. (One of the other symptoms was coughing up bubbles) nagito soon fainted since he was from a high fever since he was suffering the most.

Monokuma soon announced his new murder motive, the despair disease, a sickness that causes the infected to act like the exact opposite of who they are. Ibuki has the gullible disease, akane has the emotional disease, nagito has the lying disease, Captain Tangent has the quiet disease, Victoria Best has the inferiority disease, and leslie has the expressive disease, for now those were the only infected students. (Monokuma soon went on a random rant that the whole motive gave him a inspiration because of nocan the Contrarian, his demeanor of doing the exact opposite of what people say intriguing the bear. Soon hiyoko told him to shut up and that he was going off topic.)

becky Botsford: "d-despair disease..? we should do something about this."

bob: "squeak! squeak!"

todd "scoops" ming: "hm.. a sickness that makes people act the exact opposite.. what a scoop! I have to report this to the others!" scoops coughed out a few bubbles, he felt really tired for some reason. "o-okay... maybe this isn't going as I thought it would go.. I shouldn't have gotten out of bed... cuz now my guts feel all weird.." he sat down to take a breather before he immediately got up again and ran over to a trash can to vomit in it.

Angie yonaga: "we should do nothing!"

nocan the Contrarian: "nothing? No, nocan thinks we should do something! Nocaaaaan!"

sonia Nevermind: "huh? Angie, How did you do that?"

Angie yonaga (whispers to sonia): "easy, I say the exact opposite!"

Dr. Two-Brains (gets back up from bending down to get cheese from the fridge): "atleast it wasn't me, I mean how would I act if I was infected? Being a cheese hater? I don't want that!"

the whammer: hugs Chuck to comfort him, but notices his face went red in embarrassment "uh-oh, whammer thinks chuckie's got a fever!"

Chuck the Evil Sandwich-Making Guy: "w-wait no- it's not what y-you think!" before Chuck can even say anything, the whammer put him in a wheelchair as he pushed it all the way to a patient's room. (Sidekick of the year 😭)

mikan tsumiki: "o-oh... maybe I can take care of them... i mean I'm t-the ultimate nurse after all.."

beau handsome: sets a bunch of gift boxes on the table "I was going to use these hospital items as a prize for my gameshow, but then I realized that this is going on!" he looked stressed and anxious as he took out all the hospital supplies, pills, a thermometer, medicine, etc.

hiyoko Saionji: "well I'm not getting sick! Maybe YOU should go with her hajime!"

Hajime Hinata: "me?! Fine... Fuyuhiko, {{user}}, you two go with me, just in case."

todd "scoops" ming: "oh screw you monokuma! You're gonna pay... as sure as my name is to-" he couldn't even finish talking as he started throwing up in a paper bag before he tried to speak again. "t-todd sco-" he couldn't finish as he vomited in the paper bag again.

chiaki Nanami: "hm... I think I remember that there was a hospital on the third island."