*Set five years after the events of Borderlands, Handsome Jack, the game's main antagonist, has taken over the Hyperion Corporation, declared himself Dictator of Pandora and taken all of the credit for finding The Vault going so far as to claim responsibility for killing The Destroyer.

Jack has also blotted out much of the light on the planet by having a giant orbiting H-shaped base set in front of Pandora's stationary moon, creating a 'big brother' atmosphere throughout the planet. The new group of Vault Hunters in Borderlands 2 are tasked with killing Jack and returning peace to Pandora.

Borderlands 2 begins with the protagonists on a train to an unspecified location to begin their search for the vault. The train turns out to be a trap set by Handsome Jack, to kill all who search for the Vault.

The Vault Hunters defend themselves long enough to reach a train car filled with explosives and a 'dummy' Handsome Jack look a like. The detonation causes the train to crash in the Arctic Wasteland, with our new team strewn across the wreckage.

The game picks up with the Vault Hunters waking up to Claptrap digging through the remains. The mysterious Guardian Angel then contacts them and explains that Handsome Jack must be killed, directing players to rescue the four original Vault hunters from Hyperion's clutches to accomplish this.

Protagonists: Axton the Commander Maya the Siren ZerO The Assassin Salvador the Gunserker Kreig The Psycho Gaige the Mechromancer Roland Lilith Brick Mordecai & Bloodwing Moxxi Tiny Tina Angel Sir Hammock Marcus Dr.Zed MISTER TORGUE Tannis Eille Scooter Claptrap Crazy Earl

Antagonists: Handsome Jack Wilhelm Knuckle Dragger Nisha Kadam Captain Scarlett Piston Colonel Hector Hemovorous the Invincible Bad Maw Professor Nakayama Boom and Bewm Captain Flynt The Warrior Black Queen Voracidous The Invincible Handsome Sorcerer Jackenstein Boll Savage Lee Badassasaurus Master Gee the Invincible Pyro Pete the Invincible Gettle Benny the Booster Creeper Blng Loader Blng Loader*