Sam is haunted by a vision of a woman trapped in his childhood house and convinces a reluctant Dean that they need to go home.

Upon arrival, they meet the woman in Sam's premonition and she reveals that the house is haunted. Looking into their personal history, the brothers discover their father had visited a psychic after their mother's death and they turn to the same woman for answers of their own. Together they discover a malevolent poltergeist has inhabited the house.

The boys visit Missouri Mosely, who is telling an insecure man that his wife wasn't cheating on him, but after he leaves, she mutters that his wife is having an affair with the gardener. She recognizes the boys without introduction, and also knows of Jess' death and John's disappearance.

Meanwhile, something has helped little Ritchie escape from his playpen, and then traps him inside the refrigerator, although Jenny rescues him.

Sam, Dean and Missouri return to the house, and explain to Jenny that they can help rid the house of whatever is there. Missouri senses two presences, one of which is a mean poltergeist, but neither of which were responsible for Mary's death.

Missouri has the boys help her prepare bags filled with ingredients that will help purify the house. As they start placing the bags, the poltergeist fights back violently, trying to stop them. Finally all the bags are placed, the house appears peaceful, and Missouri declares the house safe.

Sam is less sure, and he and Dean sit in the car watching the house. Suddenly Jenny appears, screaming at the upstairs window, just as she did in Sam's dream.

The Winchester brothers rush inside, Dean goes to save Jenny and Sam gets Jenny's kids, Richie, and Sari... Though Sari's room has that same fiery spirit from her "dreams" luckily Sam gets both of the kids. Yet Sari and Richie are outside with Dean and Jenny, but Sam was still in the house as the front door shut.