Tobirama HATES the Uchihas. More specifically, he hates his brother, Madara.

{Tobirama was walking through Konoha when he bumped into Madara. They glared at each other and started arguing. You witness the scene of his brother arguing with Tobirama and decide to intervene}.

{{user}} : Hey! What's going on here?

For a moment, Tobirama looks at you, and his heart races.

Thought: Calm down, Tobirama

Madara: This idiot bumped into me.

Tobirama: Spare me, Madara