Outside a bar, Sam is reading a paper about the mysterious death as Dean comes to Sam with money in his hand. Dean hustled money by playing pool. Dean said he would rather take a "fun and easy" way rather than an "honest" way of making money.

Sam then brings up the article he read about how Dustin died due to Creutzfeldt–Jakob Disease (or CJD, known as the human form of Mad-Cow Disease). Dean confesses that he has only heard of it on Oprah, to which Sam asks, "You watch Oprah?". Dean wonders why it would be their problem. Sam explains to Dean about CJD and how the symptoms don't match; Dustin would have been displaying symptoms of it for months or years before dying of it. Dean and Sam then drive to Oklahoma.

Now the duo drive over to the location and find out they're building new houses and the sellar, Larry talks to them once Sam and Dean come over to the BBQ (for a secret investigation.)

Dean talks to Larry in private as Sam chats with Larry's weird and bug obsessed son Matt.

Days later one of the ladies working for Larry died, so they find Matt at his bus stop and notice him walking in the opposite direction from his house. They follow him into a wooded area. Matt gets nervous and asks if they are serial killers, to which Sam and Dean comfort him with a "no".

They question him about his bugs and how Linda died due to spiders. Matt gets defensive because he knows that he didn't do the killings. Matt does confess that he knows something weird is happening with the insects and goes to show them an example.

On the walk to where Matt is taking them a discussion about family comes up. Sam assures Matt that things will all get better in two years (he is 16), when he goes to college. Dean thinks that it's bad advice because a kid shouldn't leave his family.

Once deeper into the woods Matt shows Sam and Dean that many insects from Earthworms to Bees have all been congregating in the same general area. Sam points out a large dirt mount where many worms have been. Dean goes digging through and finds a skull.

Dean and Sam bring a box of uncovered skeletons from the same area where they found the skulls. They decide that it was a spirit channeling through bugs. They then get into another discussion about their father. Sam feels that their father was always disappointed in him. Dean says that he wasn't disappointed, but scared, scared something might happen to Sam if he was all alone.

Now they talk to a professor of a university about the bones and apparently they're native american. Sam questions and asks if there were any tribes within the vicinity. The professor says something about a Euchee tribe about 60 miles from where they were.

A Native American is playing a game of solitaire as Sam and Dean go inside to talk to him. The man can tell Dean is a liar and Sam isn’t. The man answers any questions Sam has. The man confesses to knowing about the area of the construction site.

They tell him about the Native American bones they found, so the man tells them a story that has been passed down for generations. He tells them a story of a tribe that was systematically murdered for six nights following the Spring Equinox, and about how nature will protect that valley for the six nights after “the moon and sun share the sky as equals”, and that after the sixth night, not a single white person will be left alive.

The nature he is talking about is the bugs...

Sam and Dean then realize that it is the sixth night, so they have to get Matt and his family out of there.

Sam calls Matt and tells Matt about the situation and how he has to get his family out of there. Dean takes the phone and tells him to lie in order to get them out of there.

Matt is unable to get his family out of the house because he told the truth and his father doesn’t believe him. After arguing, they see the whole swarm of bugs coming. It is too late to get to the car, so they all run into the house.