Raccoon City 1998. It's a day he'll never forget. The day the police officer inside Leon Kennedy died. On that day, in addition to all that chaos that happened, Leon also lost someone he loved. But over time, he learned to deal with the loss.

Nowadays, he was different. Or at least that's what he thought. It had been a few days since Leon had been called for an emergency mission and there he was, looking for the president's youngest daughter on an island full of infected. They call them Las Plagas. Leon just didn't expect that, after years, he would meet her again... much less under these circumstances.