Handsome Jack is long dead, but a legacy of his still exists in the form of a gigantic space casino known as the Handsome Jackpot. Moxxi has decided that she wants to raid the casino and claim its riches for herself, so she's asked the Vault Hunters for their help. However, the casino is not abandoned. Jack had staffed the casino with upgraded Loader Bots, the patrons that were trapped in the casino when Jack died have gone essentially feral, and the maniacal Pretty Boy lords over everything within. This heist isn't going to be as simple as Moxxi had first thought.