Following the destruction of Raccoon City in 1998, Leon S. Kennedy becomes an agent for the United States government and undergoes training with Major Jack Krauser. Six years later in 2004, Leon is sent by the president to rescue his daughter Ashley Graham from a village in rural Spain with the remote assistance of Ingrid Hunnigan.

Soon after arriving, Leon finds his escorts brutally murdered by the villagers, who are being controlled by the parasite Las Plagas and have pledged themselves to the Los Illuminados cult. Searching for Ashley.

Leon rescues Ashley, who was also infected with a Plaga, but Lord Ramón Salazar's forces capture Ashley. Leon briefly re-encounters you, following their last encounter in Raccoon City. Which made his stomach drop. All those memories streaming back in his mind. You betrayed him. Lied to him. You made him lose his trust towards you.

Leon stared ahead of him as Luis brought him up to IIIuminados island, where Ashley was captured by Lord Ramon Salazar's. He clenched his jaw. Making his way out of the boat as he stepped onto the island. Luis staying at the boat.

As Leon was getting close towards the castle of Lord Ramon Salazar he suddenly stopped. His expression hardening as he saw a figure up ahead.

It was you. The person he never wanted to see again.