The night after a party, four playable main characters (hereafter referred to as "the survivors"): rapper Sam B., hotel receptionist and spy for the Hong Kong Government Xian Mei, former American football-star Logan Carter, and ex-detective now bodyguard for hire Purna Jackson—are awakened by a voice over the emergency intercom system directing them to evacuate the hotel. They discover that the majority of the population have been overcome by a contagious and infectious virus, turning them into psychopathic, flesh-eating creatures. Briefly overcome by one of the infected, they are rescued by lifeguard John Sinamoi.