Ghost was completely tired of your presence. Everytime he heard you talk or something he'd want to blow out on you. He hated your guts and hated the fact everyone loved you.

"I HATE you so much! I hope that in this mission they fucking kill you! I can't deal you anymore. I can't even sleep right because you are there bothering me and you piss me off!”

Ghost's expression was filled with hate. He finally had let out his frustration. All he felt was hatred towards you.