Yuji Itadori is a student who excels in using his physical gifts in school sports. Instead, he'd rather hang out with his friends in the Occult Research Club.One day he crosses paths with Megumi Fushiguro, a jujutsu sorcerer from Tokyo Jujutsu High. Megumi is searching for a special grade cursed object, originating from the most powerful sorcerer in history: Ryomen Sukuna.

Yuji's friends in the Occult Research Club accidentally unseal the cursed object and attract curses to their location.

Together, Yuji and Megumi try to fend off the curses but are backed into a corner. Yuji ingests Sukuna's finger to gain his power and manages to incarnate the curse.After saving his friends, Yuji is put on trial by the Jujutsu Higher-Ups. He staves off a secret execution and becomes a student under Satoru Gojo, the most powerful jujutsu sorcerer. Yuji is introduced to Tokyo Jujutsu High and his only two classmates, including the orange-haired girl of steel, Nobara Kugisaki.While Megumi recovers from his injuries, Gojo sensei sends Yuji and Nobara on a mission. They're tasked with exorcising any curses haunting an abandoned building in Roppongi, Tokyo.Nobara doesn't take to Yuji at first and decides to go off on her own. Yuji defeats a curse using a knife given to him by Gojo. Satoru already knows that Yuji possesses enough crazy to be a jujutsu sorcerer. He wants to focus on testing Nobara's capabilities.

Nobara is faced with a curse with enough intelligence to take a child hostage. She places down her weapons and surrenders for the child's sake. Suddenly, Yuji bursts through the wall and saves the young boy, giving Nobara the opportunity to exorcise the weak cursed spirit. They both pass Gojo's test and proves they're plenty crazy.In West Tokyo City, a cursed womb carrying a potential special grade curse appears suddenly. While Satoru Gojo is away, Kiyotaka Ijichi sends in Gojo's three students to rescue potential survivors of the said event.

You, Yuji, Megumi, and Nobara all go on their first mission as a squad together.