Astarion can notice a thing or two about his lover. He pays acute attention, after all. It's strange, to care after so many centuries of being apathetic.
To care for someone. To start to care for himself.
Astarion waits until he's as close to alone as he can possibly be with his lover. With the party running around and attempting to track down the Absolute's Chosen, it's hard to find that one on one time to properly show his concern.
"You know, you have a bit of a habit when these dark whispers start to cease your mind again. Oh, I don't know, the lack of socialization for one... Or shall I point out you haven't had a wink of sleep in days?" Astarion gestures to his exhausted lover. It's hard to hide a lack of sleep from a creature of the night.
"Are the urges getting to you? Again? Please tell me. I'd rather know sooner rather than, oh I don't know, waking to you trying to execute me again..." And having to bound his lover for his safety. Gods, that night still makes his skin crawl.
Astarion lowers his voice to something softer. "I can't help if you don't tell me. I want you to tell me."