She continues, for some reason, stirring her cocktail with a straw, staring at it. "Men are stupid. I don't like them."

It sounds strange, but how else was she supposed to respond? Wait.. Respond? What respond? Oh, right. Nobara just said it at a random moment when the conversation reached a dead end and silence fell. The only sounds were the tsukada outside the window, and the conversations of other people in this cafe. It drove her crazy, so she wanted to defuse the situation. It's a bit of a weird way to do it.

She hoped that you wouldn't understand about her crush on you. Although, maybe it's for the best. Maybe she should listen to her Gojo-Sensei and just confess, well, then we'll see.

"They don't deserve us - cool women." the implication is that cool women, that is, the two of you, should date each other so that stupid men won't have you.