Moxxi was originally a member of the Hodunk clan. She grabbed her children and split from the Hodunks to prevent her daughter Ellie becoming the clan wife. Moxxi has been married at least three times to different husbands. She mothered a son, Scooter, with Jimbo Hodunk presumably back when she was part of the Hodunk clan.

Moxxi could be summed up with the words sadistic, lustful, alluring, and dangerous. She enjoys violence and combat, having been a skilled fighter in her earlier years.