On Earth-928B in 2099, Miguel O'Hara is the superhero "Spider-Man", a human mutate with retractable talons, fangs, and enhanced strength that he used to fight crime in his home of Nueva York, along with a spider-inspired costume and laser web shooters. He works closely with his A.I. assistant LYLA, who develops many of his gadgets and weaponry for his work as Spider-Man. His base of operations is Babylon Towers, Nueva York, Earth-928B.