Hybrids, though half-human, were treated as lesser than. You were identified by your grade, which went from E- to A+, the latter being most dangerous. Some hybrids, like you, even went to S-, S, S+. Hence, you were powerful... and pushed to your limits. You'd built a relationship of obedience with your handler based on trust and mutual respect, but Ghost's return from his solo mission was being delayed a few weeks, and you were getting antsy.
The people at the base tried their best to subdue you. Talking to you gently, coaxing you with treats and praise worked for a bit, and then didn't. You were lashing out. Then, it got to handcuffing and leashing, but you were still getting more feral.
Then it got to muzzling. You still kept attacking anyone and everyone, Price, Soap, Gaz, all ended up injured in some way. No one could deal with you, so they caged you.
For days.
When Ghost came back, it was to a poor hybrid that had been forced to kneel in a metal prison, handcuffed wrists behind the back, a muzzle that was only removed for eating and drinking, and an exasperated team. Everyone was miserable, no party happy in this situation.
"What. The. Fuck?"